Endocrine Abstracts

Introduction: In a recent study, it was determined that morbidity rates due to cardiovascular diseases were affected as a result of long-term follow-up in patients with nonfunctional pituitary adenoma. And cardio/cerebro vascular diseases were the most frequent cause of mortality when mortality rates were examined. In the literature, there are not enough studies evaluating this condition in patients with nonfunctional pituitary adenoma without traditional cardiovascular risk f...

Introduction: Neutrophil/lymphocyte (N/L) ratio is considered as a sign of systemic inflammation in recent years. In our study, we aimed to investigate N/L ratio in hyperthyroid patients and healthy control group.Material & methods: A total of 121 hyperthyroid patients (71 patients with Graves’ disease and 50 patients with other causes of hyperthyroidism) and 40 healthy volunteers were enrolled. Complete blood count was obtained from both group ...

Due to inhibition affect on proliferation, motility, resistance to apoptosis and growth of metastasis, the epidermal growth factor receptor (EGFR) inhibitor erlotinib and vascular endothelial growth factor receptor (VEGF) and EGFR inhibitor vandetanib are viable treatment options for treatment of advanced non-small cell lung cancer and thyroid cancer respectively. Advanced non-small cell lung carcinomas (NSCLC) or medullary and differentiated thyroid carcinomas (MTC and DTC) m...

Introduction: Bilateral adrenal mass presents a unique diagnostic challenge and carries additional risk of being metastasis. The differential diagnosis of bilateral adrenal mass include primary or secondary neoplastic disorders (adrenocortical carcinoma, lymphoma, metastases), pheochromocytoma, longstanding congenital adrenal hyperplasia and macronodular adrenal hyperplasia, infections such as tuberculosis, histoplasmosis and blastomycosis.Case: Thirty-f...

Background: Acne, stria and decreased skin elasticity are dermatological features of Cushing’s syndrome (CS). Although it is known that collagen mass in skin is decreased in CS and glucocorticoids play a role in acneiform skin lesions, the dermatological findings of CS has not previously been measured by reliable methods.Objective: The aim of the present study was to measure skin elasticity, capacitance, sebum content, pH and temperature in CS befor...

Hashimoto’s thyroiditis is thought to result from the decreased of T helper type 2 (Th2) responses, leading to progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) is a recently described member of the IFN-λ family and has been shown to decrease production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in Hashimoto’s thyroiditis remain unkno...

Purpose: The purpose of this study was to analyse ghrelin concentrations in the umbilical cord of pregnant women with a diagnosis of gestational diabetes mellitus. The relationship between ghrelin concentrations and birth weights was investigated.Methods: Sixty pregnant women with gestational diabetes mellitus and 64 healthy pregnant women with three oral glucose tolerance test results within normal limits were included in the study. Following birth but ...

Introduction: Adrenocortical oncocytomas are rare seen tumours. Most of these tumours are benign and non-functioning. We present here a case of oncocytic adrenocortical tumour, detected incidentally, presented with Cushing’s syndrome.Case: A 41-year-old male patient, while investigating for abdominal pain, bilateral adrenal masses were detected in abdominal ultrasonography and was admitted to Endocrinology Clinic. He had no history of hypertension. ...

Aim: To evaluate the effect of androgen replacement therapy on lipid profile and platelet aggregation in in male patients with isolated hypogonadotropic hypogonadism (IHH).Material and methods: 36 male patient, mean age 32.2 (18–54)with IHH, admitted to the outpatient clinic of Endocrinology and Metabolism were included to the study. Patients in the study were divided into two groups as Testosterone (n=18) and human chorionic gonadotropin (...

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive period, and it has been considered as a risk factor in cardiovascular disease due to increased prevalence of hypertension, dyslipidaemia, obesity, and insulin resistance. Platelets have a pivotal role in the development of atherothrombosis. Platelet distribution width (PDW) is a marker of platelet size that reflects the heterogeneity of the platelets. This arithmetical inde...